secobarbital will lessen the extent or effect of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.secobarbital will lower the level or effect of conjugated estrogens, vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.secobarbital will lower the extent or effect of midazolam by a